The collision happened about 11 am when a Honda Jazz, driven by an 83-year-old man from Dumfries, was in collision with an Audi A1 car driven by a 69-year-old woman from County Donegal in the Irish Republic.
The drivers were helped from the vehicles by Scottish Fire and Rescue personnel and, along with the 58-year-old female passenger in the Audi car, were conveyed by ambulance to Dumfries and Galloway Royal Infirmary.
The driver of the Audi car suffered a broken ankle while the two other casualties were treated for minor injuries.
There was some disruption to traffic on the busy Gretna to Stranraer route with the road closed for a period.
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