Bridge of Dee, Twynholm and Kirkcowan have all been targeted over the same night, sparking a Police Scotland investigation.
DC Andrew Santangelli from Police Scotland said: “This is a very large number of crimes to have happened in the one night and clearly they may well all be linked.
“We have been carrying out door-to-door enquiries in all the areas and are currently examining CCTV footage which covers some of the areas.
“We really need the help of the public to help us catch those responsible for what are quite disturbing crimes.”
He added: “The fact that those committing these crimes chose to enter houses where people were asleep in their beds is very unusual for our area.
“One concerning aspect is that of all 12 crimes, only one needed force to overcome the security of the house or vehicle.”
Overnight on Thursday January 5, property including cash and jewellery were taken in some cases, whilst in others, nothing was taken.
In three of these incidents, the intruder was disturbed whilst actually in the house, two within occupied bedrooms.
A 13 year old girl, a 63 year old woman and a 35 year old woman were all awoken from their sleep by an intruder in their separate homes at about 6 am on Friday.
In Arden Road in Twynholm, a house was the subject of an attempted break-in and a hat and jacket were stolen from a Suzuki Vitara car.
In Main Street, Kirkcowan, two houses and the village hall were entered overnight and a quantity of cash stolen.
Anyone who is able to provide information is asked to contact Police Scotland on 101.