The Kawasaki KXF450 was taken from the address in St Conals Square between 4.45 pm and 5.30 pm on Monday.
It is black and green with Monster Energy graphics, a Pro Circuit racing exhaust system and green alloy racing foot pegs.
PC James Kirkpatrick said: “This theft has happened over a very short time period and we are keen to hear from anyone that saw anyone pushing this bike away from St Conals Square.
“The bike is very distinctive with a number of non-standard parts fitted and I would ask anyone with information to contact me at Sanquhar Police Station on the 101 number.”