Police and emergency services rushed to the collision near junction 20 northbound near Eaglesfield at 3.55 am this morning.
Both the 54-year-old driver of the Mercedes saloon, and the 46-year-old female passenger were taken by ambulance to Dumfries and Galloway Royal Infirmary for treatment.
The man is being treated for serious injuries that are not believed to be life-threatening, and he is currently in a stable condition, while his passenger only required a check-up.
Police are currently carrying out enquiries as to the cause of the crash. All vehicles involved were recovered and the road was reopened by 7 am.
Man hurt in M74 crash
A CRASH between a car and a lorry on the A74 motorway this morning has left a 54-year-old man needing treatment for 'serious injuries'.
Five-star Athletic!
FIVE goals from five different goalscorers against Dumbarton last Saturday helped Annan Athletic open up an 11 point gap between themselves and the bottom two teams in League One
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