Paul Farley, 42, was last seen in his home of Coppull, Chorley on Sunday afternoon when he left home to buy cigarettes.
He is thought to be travelling in his white Renault Kangoo van which was spotted on the M6 north bound today travelling towards Cumbria.
Mr Farley is also known to visit Scotland and may have links to Dumfries.
He is described as white, 5ft 6 tall with short grey hair – pictured. He was last known to be wearing a blue crew neck top and black trousers.
PC Lee Tickle, of Chorley Police, said: “We are growing increasingly concerned about the whereabouts of Paul and would urge anyone who may have seen him or who knows where he may be to get in touch as soon as possible.
“Similarly, I would urge Paul if he sees this appeal to get in touch to let us know that you are safe.”
Anyone with information should call Lancashire Police on 101 quoting log number 0237 of October 26th.