The company, which is part of Globus Group and specialises in worker safety solutions, initially announced in September that NHS orders had dried up.
It led to the closure of their Lochside factory in Dumfries with the loss of 65 jobs.
And now the firm is considering the future of its Annan operation, with a consultation underway.
An Alpha Solway spokesperson this week said: “Following the announcement last month of the closure of our Dumfries site as a result of the significant financial impact caused by the lack of NHS orders, we can confirm that we are reviewing staffing and operations at our Annan factory.
“A formal consultation process is underway but no decisions have been taken on whether this will result in redundancies and, if so, in what numbers.
“We remain committed to manufacturing in Scotland and would like to thank our colleagues for their hard work over the last two years.”
Earlier this year Alpha opened a new factory at Gilnockie Business Park in Dumfries at a cost of £12m – part of a £33m investment into the region in partnership with the South of Scotland Enterprise – to ensure a fast resilient supply of PPE manufactured in the UK.
At the time it was expected that 300 new jobs would be created there, but the Annandale Observer understands that there are only a handful of workers currently employed at the site and new equipment is lying there gathering dust.
The situation faced by Alpha was raised in the Scottish Parliament by Colin Smyth MSP.
He voiced his concern over the need to have a domestic supply of PPE produced in the UK and said: “One of the biggest lessons from the pandemic is the need to never again find ourselves in a position as a country where we have to rely on importing PPE.”