At least two vehicles are understood to have been involved in the collision at Amisfield this morning.
A spokeswoman for Police Scotland said: “At about 9.20 am there was a road crash on the A701 near Amisfield.
“It’s a car into a lorry.”
Several police patrol cars, fire engines and ambulances were seen heading to the scene of the collision.
And the police spokeswoman said: “They’ve closed there and diversions are in place.”