The temporary closure of the B722 Lady Street will be in effect from 8 am to 5 pm, Monday to Friday, and marks the start of six weeks of work in the centre of town.
A spokeswoman from Dumfries and Galloway Council said: “Planned refurbishment work of traffic signals at the High Street/Lady Street/ Bank Street junction in Annan are due to commence on Monday September 19.
“These works are part of the council’s traffic signal refurbishment programme as agreed by the economy, environment and infrastructure committee.”
She added: “Molplant Construction Ltd will be carrying out these works which are scheduled to last for six weeks and include footway improvement works and traffic signs rationalisation.
“The opportunity will also be taken to undertake planned carriageway resurfacing of the approach roads to this junction following on once the traffic signal works are complete.”
When plans were revealed earlier this summer, Annandale South councillor Ian Carruthers asked why elected members and the town’s community council were not consulted over the works.
Dumfries and Galloway Council have addressed anticipated disruption resulting from the works.
A spokeswoman said: “During the works temporary traffic lights will control traffic and pedestrian movements.
“Delays can be expected and drivers are asked to try and avoid the area or take alternative routes.
“However, measures are in place to minimise disruption, including manually controlling the lights during the peak periods.”