Saskia Sievewright was last seen in Glasgow City Centre at around 11 pm last night, having travelled to Glasgow from the Annan area.
She is described as white, 5ft 6” in height, stocky build with shoulder length blonde hair. When she was last seen she was wearing a grey tracksuit top and jogging bottoms. She may have also had a red top on.
Constable Richard Davidson of Gretna Police Office said: “Although Saskia has been missing before on a number of occasions, she is only 16 years of age and we need to know that she is safe and well.
“Enquiries are continuing today to trace Saskia and I would ask anyone with information on her whereabouts to contact Police Scotland on 101.”