The raid happened between Saturday June 20 and Friday July 10 in Pleasance Avenue — a busy through road on the west side of the River Nith.
Detectives say the high value haul included a tanzanite and diamond ring, bracelet and necklace, an emerald and diamond ring, bracelet and necklace, pearl necklaces and a number of diamond rings and earrings.
A sum of money was also taken by the intruder or intruders.
Detective Constable Lorna Douglas of Dumfries Police said: “We are keen to hear from anyone who may have seen or heard anything suspicious in Pleasance Avenue, in the area around Troqueer Primary School, over this period.”
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