Police officers are carrying out enquiries into a small number of reports of possible spikings in the town over the past fortnight.
The incidents are said to have taken place on Saturday February 19 and last Saturday, February 26.
Police say that enquiries are at an early stage and there is no evidence currently to suggest that the reports are linked.
Inspector Anna Boyd, from Dumfries Police Station, said: “We are carrying out a number of enquiries, but can confirm at this time that we have no confirmed cases in the Dumfries and Galloway area.
“Our community officers will be carrying out extra night-time patrols this weekend and engaging with the public and licensees to provide reassurance.
“We take all reports seriously and encourage anyone who believes they have been a victim of spiking in any form to contact police by calling 101.”
As a result, Alpha Security – who provide doormen at a number of pubs and clubs across the region – say that there will be more “random bag and person searching on entry”.
A spokesman added: “Anyone who may feel discouraged or have any questions or information in relation to spiking, should feel free to approach any member of the Alpha Security team or bar staff within your chosen venue.
“The safety of our staff and the public are our main priority and anyone caught will be treat accordingly.
“If you feel you are a victim of a potential spiking case, then again please do not hesitate to approach one of our staff members, as they are all trained to deal with any given scenario.
“Stay safe and most importantly, help us to help you stay safe.”
And Dumfries hotspot N’Dulge posted on their social media saying they consider the “alleged spiking/injections” a “threat” to their customers.
An N’Dulge spokesman added: “We will be increasing our security checks within the premises. We hope you will understand if we introduce random searches on entry.
“We also remind customers their safety is our priority and in the event of such an incident happening or suspicion of this sort of activity happening please approach security or a member of bar staff with information that will remain confidential and be dealt with accordingly. The safety of the public are our main priority.”