Officials have outlined a range of actions that can be taken and number one is taking up free flu and covid vaccinations when offered.
They say this will reduce the number of people who will need help over the winter.
Wearing face coverings on NHS sites, and offering flexibility and support to get loved ones home from hospital are also advised.
Nicole Hamlet, from Dumfries and Galloway Health and Social Care Partnership, said: “Very honestly, we’re in a very tough situation at the moment.
“I don’t think we’ve ever seen this sort of pressure on our system at this time of year – not even during the worst of covid.
“If we’re going to pull through this, it’s by everyone in the region recognising the seriousness of the situation and working together to get us through these winter months.”
She also reminded those visiting NHS buildings to wear face coverings to help limit the spread of infection and asked visitors not to enter hospitals if they feel unwell with flu or covid symptoms.
Ms Hamlet added: “Our request is again all about limiting the risk of infection, particularly at a time when services are already functioning under great strain.
“People are likely aware that one of the biggest challenges our system faces is having enough carers to support people to get home, or continue living in their own home.
“If you have a relative or loved one who is currently delayed in hospital due to a shortage of care packages, you can help by being as accommodating, flexible and supportive as possible. Arrangements may not be ideal at this challenging time, but it’s not to anyone’s benefit if your loved one is spending time in a hospital bed when they could be at home.
“We don’t want to add to the pressures already being faced by individuals, but where families and friends can offer to do more this would be met with a very genuine appreciation.”
But she noted that anyone requiring emergency treatment is still encouraged to come forward, but stressed that the hospital emergency departments are for ‘very pressing’ emergencies only.
Advice and support is available online at www.nhsinform.scot or by calling NHS24 on 111.